lucose degradation products and the peritoneal mesothelium.

Abstract\n conventional heat-sterilized, glucose-based peritoneal dialysis (PD) fluids contain momentous amounts of glucose degradation products (GDPs) such as aldehydes and dicarbonyl compounds (glyoxal, methylglyoxal). These GDPs have been shown to impair kiosk functions in various in vitro experimental models. In peritoneal mesothelial cells, GDPs dose-dependently inhibit cell proliferation and intermediator synthesis. In addition, some GDPs powerfully promote generation of innovational glycation end-products ( whiles). Immunohistochemistry finds AGEs in the peritoneal tissue layer of chronic continuous ambulant peritoneal dialysis (CAPD) patients, suggesting that peritoneal AGE accumulation may be involved in chronicperitoneal fibrosis. The governance of GDPs might be prevented by filter-sterilization of PD fluids. Another filling is to separate the glucose and the buffer organisation in dual-chambered or multi-chambered containers. In these systems, the glucose is kept in a separate compartment at gritty concentration and very mild pH-both conditions being known to denigrate the degree of glucose decomposition during autoclaving. initial experimental evidence suggests that these novel, multi-chambered fluids significantly improve in vitro biocompatibility; however, the clinical relevance of these results remains to be established in clinical trials.If you want to get a full essay, order it on our website:

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