Cathlicism

4)In proliferation of b booths , a stem carrelular phone interacts with the stroma cells in the evolve marrow. Cytokines from non lymphoid cell signals promotion of cell survival and bear witness proliferation early in the b cell linage. Chromosome 14 codes for the rotund chain rearranges from the germ line. A d- J divisions rearranges and join to undertakeher forming dj unit at pro b stage. Makers such(prenominal) as cd 19 cd10 are place on cell to chink maturation and proliferation. The cell differentiates from Pro b to Pre B cell. A second rearrangement fade involving v region. The v joins to the dj forming vdj segment for the slow chain. A second chromosome is rearranged forming the U chain. The pre b cell is now associated with surrogate light and U chains in conjunction with a ig a ig b complex known as pre BCR. Ig a igb stand by cell to transmit messages to the nucleus. The pre cell and so proliferates into a unfledged B cell. Cd10 is drop an cd 20 i s Kapp found on chromosome 2 and gamma found chromosome 22 rearranged, transcribed, spliced and translated to form a light chain. Allelic exclusion come ups twain sonorous and light chain form either immunoglobulin M or igd. A thymus dependent reaction ascertain for elucidate switching, cytokines like inf y and il-5 are produce by t help cell. A second rearrangement takes place for the toilsome chain.

Class switching recombination happens, the unremitting region genes has s region. The cytokine stimulates unending mu and epsilon to be synthesis b cell then sectionalisation switch primary rna is transcribe sp lice do n a fundamental gamma chain do fo! rming an igg. 5) cd20 is molecule that found on the surface of immature b cell. It function is to bring calcium in the cell. Calcuim is need for the energizing of transcription factors for immunoglobins genes AP-1. If anti 20 molecules binds to it this mean that the second rearrangement of the heavy chain cannot occur resulting in anergy or apoptosis because the cell will cannot mature when expose to antigen. This is what Ive got so far...If you want to obtain a full essay, order it on our website: OrderCustomPaper.com

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